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Have a severely detrimental effect on
blight mar crush destroy frustrate ruin spoil wreck dash undo disrupt end prevent quash quell scotch demolish devastate sabotage shatter banjax crool dish foul up nix play havoc with queer scar scupper stymie annihilate cruel disfigure do in euchre louse up make a mess of mess up nullify put an end to screw up stain afflict bring to an end damage decay disappoint impair injure put a stop to taint trash make a hash of put paid to blow a hole in bring to naught put the kibosh on put the lid on put a damper on throw a spanner in the works of throw a monkey wrench in the works of vitiate harm defile blemish poison pollute hurt tarnish corrupt smash debase deface cripple ravage break contaminate compromise infect undermine torpedo sully flaw endamage dirty desecrate foul blast wreak havoc on cross up crab bloody total upset befoul waste do for pervert mangle weaken blot blow desolate soil deprave adulterate deteriorate maim decimate besmirch overwhelm raze despoil defeat vandalize warp degrade subvert deform debauch touch profane mutilate distort overturn disfeature wound pulverize nuke prejudice vandalise corrode sink pulverise wipe out thwart darken foil rot lessen uglify hinder cheapen impede jeopardize disable vaporize botch discolour discolor smirch ruinate cream scratch shake up vaporise lay waste jeopardise be detrimental to rough up wear away muck up tear down overshadow pull down bring to ruin bring down rub out blacken lay in ruins influence violate bruise reduce to nothing cloud demean interfere with diminish worsen muller radioactivate gut destabilize muddy debilitate reduce demoralize rust fester crack dishonour enervate make impure threaten incapacitate impoverish dent knock enfeeble alloy dismantle disintegrate ding tweak dishonor ravish wrack bodge demoralise disgrace bust invalidate extinguish scorch batter scourge wither devalue dilapidate wreak havoc with overthrow make unattractive sap run through spread to smash up make ugly destabilise do damage to spread among level make filthy cause detriment to make useless put out of action break up put out of commission water down cancel out negate neutralize render ineffective plague blotch speckle obliterate blunt decrease tag affect neutralise finish contort misshape mess bring about the downfall of depress devitalize trouble disarrange disorganize disturb disorder be the ruination of topple trounce make of no use or value endanger unfit devaluate disqualify impact overcome lay waste to envelop in gloom brutalize brutalise delay hold up hamper convulse slow retard obstruct unsettle burst explode pop tar slaughter destruct tumble strike shock inconvenience imperil turn upside-down derange slow down perturb lower depreciate sour color colour put the skids under doctor spike lose strength cause confusion in cause turmoil in throw into disarray throw into disorder throw into confusion take out detract from chasten fell smite chastise bastardize inflict prostitute abase consume be the ruin of seal the doom of plunder depredate sack pillage squash spoliate occur prevail begrime rattle blow up write off crud up disfashion do harm to cause the loss of cause the sacrifice of result in damage to lead to the end of result in harm to cost impinge take apart embitter envenom toxify litter infest smear check throw a monkey wrench into be a blot on the landscape impact on prevail over impinge upon cast a shadow over baulk be prejudicial to put at risk be disadvantageous to baffle strike down strike at bring to nought balls up cook someone's goose upset someone's apple cart splash besmear bastardise ulcer sore canker bestialize animalize circumvent take hold of attack be deleterious to enthuse disease move balk muck gaum mire distain spatter grime bemire smudge daub exert influence on have an effect on have an impact on cast gloom over confound waste away bilk abuse lacerate maltreat split burn tear scathe gnaw wrong spot bleach fade stab bring a note of sadness to cast a gloom upon cause injury bang up tamper with cast a pall over take the fun out of take the enjoyment out of take the pleasure out of make dirty play merry hell with drive a nail into the coffin of flatten dampen chill deplete burst one's bubble decompose knock down leave in ruins reduce to rubble bring to nothing wreak havoc upon clean out leave desolate perish putrefy bend detract mortify break down shrivel moulder molder crumble mold degenerate go bad sphacelate necrotize go off mildew turn sicken grow moldy shrivel up curdle be impaired dissolve dry-rot mould suppurate putresce become contaminated cut twist wrench mark maul pull gash rend slash torture scrape nick sprain strain rick mishandle hit shake hack butcher cleave rip mangulate mistreat rive distress fracture crick score chip graze ill-treat lame traumatize crash hamstring sever dismember incise erode handle roughly tear apart slit molest manhandle ill-use bully buckle pain beat torment traumatise notch dislocate risk knock about paralyse prostrate slice paralyze hazard kick around mess over knock around outrage menace rupture peril misuse exhaust expose dump on jeopard attenuate adventure shiver oppress venture snick snap grieve cramp screw bungle malform put in danger put in jeopardy gamble with expose to danger be a danger to leave vulnerable pose a threat to squinch victimize splinter gouge shred gnarl stretch puncture insult immobilize abrade fragment pierce treat badly cut up victimise bust up carve persecute sunder handicap cut open beat up vilify denigrate claw unstrengthen immobilise separate chop disarm chance detonate eradicate harass sting eat away clip pinch jar emasculate condition limit annoy suppress bollix disempower bother knot skew offend muff fumble hack up blaspheme sadden slap wince roughhouse flub neglect wing restrict aggrieve fluff dissipate treat roughly cut to ribbons ribbon change undercut bow do mischief to torpefy impress foozle mismanage bobble prang hash stifle bumble rack knock for six treat sacrilegiously kink inactivate boggle dub have a bad effect on have a negative effect on do over murder boot hogtie hock kibosh unbrace muzzle pinion hog-tie lance cut to pieces bung up drag through the mud treat with disrespect disenable goof up do badly knock out shoot down render incapable make a muck of make a Horlicks of throw monkey wrench in bollix up rift dash to pieces put out of joint leave defenseless divide lay open lay on the line make unclean crack up wrack up make a pig's ear of put someone's life on the line rip up overexert use up brand push whittle worry jostle shove hustle harry pull the rug out from under shear paw crumple harrow agonize jeopardy chew up dislodge make misshapen distort the shape of jigsaw age craze fissure curb spray paint overburden overtax misemploy squander overwork burn out minimize belittle minimise knacker shipwreck shrink bring discredit to mayhem gimp castrate truncate massacre roust bankrupt slay cut about mash flay agonise bend out of shape bowdlerize expurgate censor nip furrow efface season wax pique clip wings lay up disserve palsy sideline dislimb knife knock off balance chip away handle bundle bowdlerise amputate commit sacrilege crackle chop up make mincemeat of finish off pull to pieces part make hash of make liable chance something be careless with subject to loss halt damage beyond repair tear up run onto the rocks pile up supplant make lame jag savage devour streak draw blood strike at the foundations stop jam pound take the edge off sap the strength of disestablish dethrone oust depose unseat splotch imprint infringe encroach on blaspheme against deactivate freeze mellow weather hash up serrate expose to risk tempt fate put on the line subject to stake leave unprotected pockmark pit slap around indispose dynamite ring crepitate sputter spall clamp wheel-clamp tatter interrupt dot splodge tear limb from limb have a negative impact on tie render inoperative prevent from working arrest prevent from moving bring to a standstill make inoperative action render inactive bring to a halt terminate cause pain to cause injury to put out work over pummelled commit sacrilege against make lose face chalk stroke blaze ink rain on someone's parade exterminate blow away raze to the ground blow sky-high blow to pieces twitch make unfit render powerless make powerless X bump do clumsily bash dispatch rebel reverse supersede capsize invert havoc misrepresent malign pummel punish flog slug whack lash flail whip spank belt pommel punch overrun trample place a limit on eliminate knock the stuffing out of misjudge fall down flounder err do something badly misconjecture make a nonsense of muddle pull a boner blunder misconstrue miscompute misapply mend make a botch of stumble miscalculate patch fail gum up annul slight whittle away assault curve block abolish affront make a hash simulate age in sandbag mine dig soften tunnel wear challenge wreak havoc defame kill grab pluck run snatch yank evulse frazzle pull apart wrest fray extract seize arch flex grimace modify sway alter transform irritate plug zap abort dig out hollow out cheat impugn discredit slander libel discomfort stir wrinkle splutter clip one's wings chip away at queer the pitch of ouch contuse stick anguish disrespect dis diss shape concern involve agitate act on poke full of holes intrude on wind become crooked make curved crook swerve become distorted deviate make crooked become curved become deformed go out of shape become misshapen make miserable crucify knock the bottom out of govern manipulate hit hard form determine control reach give offence to get throw faze bias decide work on guide open up breach impose upon do a disservice to bad mouth take advantage of trespass do an injustice to do wrong to do injury to sin against do the dirty on kick in the teeth offend against cause suffering to gnaw at bowl over knock back regard induce tell on emotionally move inspire interest relate put down tear to pieces get to bear upon impress on implicate make an impression on hurt one's feelings hurt the feelings of nibble bite melt liquefy fret eat be violent toward cut to the quick tug at your heartstrings break apart split asunder break open burn through bite into gnaw away wear through wear down bite at burn into break into place in danger put under suspicion sell out

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